Publications

2025

Antibody targeting TDP-43 mitigates pathogenic pathways induced by the cerebrospinal fluid of ALS.

Poulin-Brière A., Pozzi S., Julien J-P. 

Neurotherapeutics. 2025 Sep 11:e00737. doi: 10.1016/j.neurot.2025.e00737. Online ahead of print.

2024

Tryptophan residues in TDP-43 and SOD1 modulate the cross-seeding and toxicity of SOD1. 

Pokrishevsky E., DuVal M.G., McAlary L., Louadi S., Pozzi S., Roman A., Plotkin S.S., Dijkstra A., Julien J-P., Allison W.T., Cashman N.R. 

J Biol Chem. 2024 May;300(5):107207. doi: 10.1016/j.jbc.2024.107207. Epub 2024 Mar 22.

2023

Neuronal dysfunction caused by FUSR521G promotes ALS-associated phenotypes that are attenuated by NF-κB inhibition. 

M.C. Pelaez, A. Desmeules, P. Gelon, B. Glasson, L. Marcadet, A. Rodgers, D. Phaneuf, S. Pozzi, P. Dutchak, J-P. Julien and C. F. Sephton. 

Acta Neuropathol Commun. 2023 Nov 16;11(1):182. doi: 10.1186/s40478-023-01671-1.

 

Transactive response DNA-binding protein 43 is enriched at the centrosome in human cells.

A. Bodin*, L. Greibill*, J. Gouju, F. Letournel, S. Pozzi, J-P. Julien, L. Renaud, D. Bohl, S. Mille Millecamps, C. Verny, J. Cassereau, G. Lenaers, A. Chevrollier, A-M. Tassin*, and P. Codron*. (*equal contribution) 

Brain. 2023 Sep 1;146(9):3624-3633. doi: 10.1093/brain/awad228.

2021

Antibody-based therapeutic interventions for amyotrophic lateral sclerosis: a systematic literature review.

Poulin-Brière A., Rezaei E., Pozzi S.

Front Neurosci. 2021 Nov 29;15:790114. doi: 10.3389/fnins.2021.790114. eCollection 2021.

Other publications by Silvia Pozzi

Defective cyclophilin A induces TDP-43 proteinopathy: implications for amyotrophic lateral sclerosis and frontotemporal dementia.

Pasetto L., Grassano M., Pozzi S., Luotti S., Samli E., Migazzi A., Basso M., Spagnolli G., Biasini E., Micotti E., Cerovic M., Carli M., Forloni G., De Marco G., Moglia C., Mora G., Traynor B., Chio’ A., Calvo A., Bonetto V.

Brain. 2021 Dec 31;144(12):3710-3726. doi: 10.1093/brain/awab333.

 

Monoclonal full-length antibody against TAR DNA binding protein 43 reduces related proteinopathy in neurons.

Pozzi S*., Codron P.*, Soucy G., Renaud L., Cordeau JP., Dutta K., Bareil C., Julien J-P. (*equal contribution)

JCI Insight. 2020 Nov 5;5(21):e140420. doi: 10.1172/jci.insight.140420.

 

Virus-mediated delivery of antibody targeting TAR DNA-binding protein 43 mitigates associated neuropathology.
Pozzi S., Thammisetty SS, Codron P, Rahimian R, Plourde KV, Soucy G, Bareil C, Phaneuf D, Kriz J, Gravel C, Julien J-P.

J Clin Invest. 2019 Feb 25;129(4):1581-1595. doi: 10.1172/JCI123931. eCollection 2019 Feb 25.

 

Chronic administration of pimozide fails to attenuate motor and pathological deficits in two mouse models of amyotrophic lateral sclerosis.

Pozzi S., Thamissetty SS, Julien J-P.

Neurotherapeutics. 2018 Jul;15(3):715-727. doi: 10.1007/s13311-018-0634-3.

 

Targeting Extracellular Cyclophilin A Reduces Neuroinflammation and Extends Survival in a Mouse Model of Amyotrophic Lateral Sclerosis.

Pasetto L*, Pozzi S*, Castelnovo M, Basso M, Estevez AG, Fumagalli S, De Simoni MG, Castellaneta V, Bigini P, Restelli E, Chiesa R, Trojsi F, Monsurrò MR, Callea L, Malešević M, Fischer G, Freschi M, Tortarolo M, Bendotti C, Bonetto V. (*equal contribution)

J Neurosci. 2017 Feb 8;37(6):1413-1427. doi: 10.1523/JNEUROSCI.2462-16.2016. Epub 2016 Dec 23.

 

Peptidylprolyl isomerase A governs TARDBP function and assembly in heterogeneous nuclear ribonucleoprotein complexes.

Lauranzano E*, Pozzi S*, Pasetto L, Stucchi R, Massignan T, Paolella K, Mombrini M, Nardo G, Lunetta C, Corbo M, Mora G, Bendotti C, Bonetto V. (*equal contribution)

Brain. 2015 Apr;138(Pt 4):974-91. doi: 10.1093/brain/awv005. Epub 2015 Feb 12.

 

A mouse model of familial ALS has increased CNS levels of endogenous ubiquinol9/10 and does not benefit from exogenous administration of ubiquinol10.

Lucchetti J., Marino M., Papa S., Tortarolo M., Guiso G., Pozzi S., Bonetto V., Caccia S., Beghi E., Bendotti C. and Gobbi M. 

PLoS One. 2013 Jul 23;8(7):e69540. doi: 10.1371/journal.pone.0069540. Print 2013.

 

Mutant SOD1 induces protein secretion pathway alterations and exosome release in astrocytes: implications in disease spreading and motor neuron pathology in amyotrophic lateral sclerosis.

Basso M.*, Pozzi S.*, Tortarolo M., Fiordaliso F., Bisighini C., Pasetto L., Spaltro G., Lidonnici D., Gensano F., Battaglia E., Bendotti C. and Bonetto V. (*equal contribution)

J Biol Chem. 2013 May 31;288(22):15699-711. doi: 10.1074/jbc.M112.425066. Epub 2013 Apr 16.

 

Amyotrophic Lateral Sclerosis multiprotein biomarkers in peripheral blood mononuclear cells.

Nardo G., Pozzi S., Pignataro M., Lauranzano E., Spano G., Garbellini S., Mantovani S., Marinou K., Papetti L., Monteforte M., Torri V., Paris L., Bazzoni G., Lunetta C., Corbo M., Mora G., Bendotti C. and Bonetto V. 

PLoS One. 2011;6(10):e25545. doi: 10.1371/journal.pone.0025545. Epub 2011 Oct 5.

 

Nitroproteomics of peripheral blood mononuclear cells from patients and a rat model of ALS.

Nardo G., Pozzi S., Mantovani S., Garbelli S., Marinou K., Basso M., Mora G., Bendotti C. and Bonetto V.

Antioxid Redox Signal. 2009 Jul;11(7):1559-67. doi: 10.1089/ars.2009.2548.

 

Estrogen action in neuroprotection and brain inflammation.

Pozzi S., Benedusi V., Maggi A. and Vegeto E.

Ann N Y Acad Sci. 2006 Nov:1089:302-23. doi: 10.1196/annals.1386.035.