Around cells there is a specialized structure called the extracellular matrix, which provides support and protection. Part of this matrix forms the perineuronal net (PNN) around neurons, a kind of protective “scaffold” for these cells. In ALS, changes in the PNN have been observed, but it is still unclear whether these alterations contribute to the pathogenesis of the disease.

Our laboratory investigates how the remodeling of the extracellular matrix and the PNN takes place in ALS, with the goal of understanding their role in the disease and exploring whether they could represent new therapeutic opportunities.